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Cell-free biocatalysts that do more with less

Cascade Bio’s proprietary enzyme immobilization technology, dubbed “Body Armor”, acts as a cushion for the enzyme, enabling it to last longer, withstand tougher conditions, and work across a wider operating window than other cell-free solutions.

How It Works

1. Analyze
Millions of enzyme structures are available, each one unique.
2. Optimize
Easily customizable polymer brushes create stabilizing thermodynamic interactions.
3. Outperform
Stabilize enzymes on easy-to-use silica beads that drop into your existing processes.
4. Cascade
Long lasting biocatalysts do more chemistry with less enzyme.
1. Analyze
Millions of enzyme structures are available, each one unique.
2. Optimize
Easily customizable polymer brushes create stabilizing thermodynamic reactions
3. Outperform
Stabilize enzymes on easy-to-use silica beads that drop into your existing processes.
4. Cascade
Long lasting biocatalysts do more chemistry with less enzyme.

Total Turnover Number

Stabilization via immobilization on Cascade's resins significantly improves the longevity of enzymes, enabling more chemistry with less enzyme. This can be expressed as a total turnover number, a measure of the number of reactions an enzyme catalyzes before inactivation.

Solvent Stability

We have stabilized enzymes against various water-miscible and non water-miscible solvents. Our unique platform allows us to iterate on resin design to rationally engineer stability, significantly improving enzyme longevity under challenging solvent conditions.

Temperature Stability

Thermostabilization of enzymes using the Cascade platform enables elevated temperature operation of enzymes for exponential improvements in specific activity and provides more process design freedom. 

Reuse

Robust, covalent immobilization enables many reuses of your immobilized enzyme, further reducing the cost contribution of enzymes in your process.

100% success rate in improving the stability of enzymes we have worked with.

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But wait, there’s more.

Convenient form factor

Our technology, as a coating, can be applied to a range of solid supports from more robust 1.5mm beads to those under 100um, ensuring compatibility with existing processes

Mechanical stability & low attrition

Our resins, made of durable glass beads, resist breakdown under harsh conditions, preventing filter clogging and simplifying recovery.

Chemical compatibility

Our silica-based materials, unlike competitors' plastic ones, offer greater compatibility with a diverse range of solvents, temperatures, and pH levels.

Porogen-free

Our competitors use porous plastic beads with porogens, which are unsuitable for food and pharmaceutical applications. Our products don't rely on porogens, ensuring safer use.

Low leaching

Our materials effectively prevent enzyme detachment from the resin, which is crucial for maintaining purity in food and pharmaceutical products.

Low non-specific absorption

Our competitors' sticky products often lead to difficult recovery of the desired end product.

Our Vision

Transform chemical manufacturing by unlocking cascades of enzymes to make any molecule using biology.

Meet the Team